A rare case of epiphyseal chondromyxoid fibroma of the. Murata h, horie n, matsui t, akai t, ueda h, oshima y, konishi e, kubo t. Surgical management of a giant sternal chondromyxoid. Chondromyxoid fibroma cmf is a relatively uncommon benign bone. Jan 08, 2015 chondromyxoid fibroma cmf is a rare, benign tumor of the bone that was described by jaffe and lichenstein in 1948. B, microscopic image of chondromyxoid fibroma showing a. A case of chondromyxoid fibroma cmf involving the zygoma is presented. Chondromyxoid fibroma is a very rare benign cartilaginous tumor representing less than 0. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for imaging differential diagnosis. Males have a higher incidence, with no other demographic bias 3. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Smaller lesions are typically located in the cortex of long bones. The primary pitfall in the histopathologic diagnosis of cmf is confusion with a highgrade chondrosarcoma, owing to the atypical stellate and spindled cells set within a chondromyxoid background.
The radiological features demonstrated by xray and magnetic resonance imaging mri are discussed. Chondromyxoid fibroma is a type of cartilaginous tumor. Chondromyxoid fibroma of two thoracic vertebrae, skeletal. Chondromyxoid fibroma of the sacrum and left iliac bone md. Removal of giant sternal tumors requires extensive resection of the anterior chest. Chondromyxoid fibroma cmf is a rare, benign bone tumor found most often in the bones of the legs, arms, feet, hands, fingers and toes. The treatment of the secondary abc is based on the appropriate treatment for the underlying tumor. It was dense on plain ct scan and showed no convincing contrast enhancement. Chondromyxoid fibroma may occur anywhere in the skeleton, but almost half of the cases occur around the knee. Chondromyxoid fibroma with secondary aneurysmal bone cyst in. Chondromyxoid fibroma childrens hospital of philadelphia. It is associated with high local recurrence rates with a small risk imaging.
We present the case of a 44yearold woman with chondromyxoid fibroma of temporal bone origin. We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture, diaphyseal location. Chondromyxoid fibroma, pediatric orthopaedic society of north america posna 1 tower ln, suite 2410 oakbrook terrace, il 60181 p. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mim. The purpose of our study was to describe the mr imaging characteristics of fibroma of the tendon sheath. A chondromyxoid fibroma appears in imaging as a lesion with a border that resembles soap bubbles.
The primary pitfall in the histopathologic diagnosis of cmf is confusion. Since this is the least common bone tumor of cartilaginous origin, it is highly unusual to find this tumor in the skull. Chondromyxoid fibroma cmf is a rare benign bony tumour. An uncommon benign cartilaginous neoplasm arising from the bone. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or.
The preoperative diagnosis of chondromyxoid fibroma at an unusual location, as in this case, is difficult from the imaging examinations, or sometimes even from the histological examination of. Phosphaturic mesenchymal tumor with chondromyxoid fibroma like feature. The decisive role played by the radiologist in identifying the benign nature of the lesion is emphasized. Chondromyxoid fibroma cmf is a benign tumor characterized by lobules of spindle shaped or stellate cells in an abondant myxoid to chondroid stroma. Chondromyxoid fibroma of the sacrum and left iliac bone. Chondromyxoid fibroma cmf is a relatively uncommon benign bone tumor of cartilaginous differentiation. Chondromyxoid fibroma cmf is a rare, benign bone tumour. The imaging and tissue tests help your doctor differentiate cmf from other tumors that have a similar appearance, such as giant cell tumor, enchondroma, chondroma, nonossifying fibroma, aneurysmal bone cyst, or infection of the bone osteomyelitis. Murata h, horie n, matsui t, akai t, ueda h, oshima y, et al. The most commonly affected area is the metaphysial region of the proximal tibia and the distal femur 2. Mehta s, szklaruk j, faria sc, raymond ak, whitman gj. This is an advanced case of a benign chondromyxoid fibroma. Cmf is most often found in the long tubular bones, especially the tibia. A primary chondromyxoid fibroma cmf arising from sternum is quite uncommon tumor in thoracic surgery.
Jan 02, 2017 on mri, chondromyxoid fibroma shows a multilobulated pattern, with low signal intensity on t1weighted images and high signal intensity on t2weighted images. In fact, the literature describes 18 cases of this form of neoplasia arising in the skull, only 4 of these having originated in the temporal bone. Mri of chondromyxoid fibroma hyunsoo kim, wonhee jee. A chondromyxoid fibroma cmf is an extremely rare benign cartilaginous neoplasm which accounts for sep 24, 2018 cappelle s, pans s, sciot r.
Small generally imaging as a lesion with a border that resembles soap bubbles. To evaluate the frequency of radiologic and histologic manifestations of matrix calcification in chondromyxoid fibromas. Differential diagnosis of cartilaginous lesions of bone archives of. Plain skull films showed a round radiolucent mass with a sclerotic margin. Chondromyxoid fibroma cmf is a rare, benign tumor of the bone that was described by jaffe and lichenstein in 1948. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. The imaging and tissue tests help your doctor differentiate. Chondromyxoid fibroma cmf is a very rare, benign noncancerous tumor that most often develops in older children and young adults. Tumors located in the distal extremities such as the hands or feet may only present clinically with signs of painless swelling 5. If you have symptoms of cmf, your doctors will use imaging scans such as xrays, ct, and. It is associated with high local recurrence rates with a small risk aug 07, 2016 chondromyxoid fibroma location. Chondromyxoid fibroma, or cmf, is a tumor of the cartilage found between your bones. Chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation. Radiological evaluation of a chondromyxoid fibroma published.
Chondromyxoid fibroma definition of chondromyxoid fibroma. Backgroundchondromyxoid fibroma is a rare benign primary bone tumor of cartilage. Chondromyxoid fibroma is a rare benign bone tumor accounting for approximately 1% of all benign bone tumors. The possibility of chondromyxoid fibroma should always be considered when a focal bone. Clinical usefulness of thallium201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma.
To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton. The age range of the patients was 370 years average 29 years. The classic site of involvement is the metaphyseal region of long tubular bones, usually presenting in the second to third decades of life with nonspecific pain and swelling of the affected part. To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton exclusive of the cranium. The possibility of chondromyxoid fibroma should always be considered when a focal bone lesion is evaluated that has geographic bone destruction, a sclerotic rim, lobulated margins, and septation. Clinical usefulness of thallium201 scintigraphy and magnetic resonance imaging. Chondromyxoid fibromas demonstrate enhancement on postcontrast ct views.
Representative radiologic images of pelvic chondromyxoid fibroma. Citations may include links to fulltext content from pubmed central and. We report on a case of chondromyxoid fibroma involving two adjacent thoracic vertebrae with features of aggressive behaviour on radiographs, ct and mri. Typically located in the long bone metaphysis, it can invade the epiphysis, especially in adults. Details of the image chondromyxoid fibroma modality.
It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. Radiological evaluation of a chondromyxoid fibroma heighpubs. Anderson cancer center chondromyxoid fibroma of the sacrum and left iliac bone sumit mehta1 janio szklaruk silvana c. Sep 23, 2016 chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. Pubmed comprises more than 26 million citations for biomedical literature from medline, life science journals, and online books.
In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings. Cartilage is a rubberlike tissue that cushions and protects the ends of your bones, sits in between the disks in your spine, and makes up the ear and nose. Department of oral pathology, emory university a case of chondromyxoid fibroma in the mandible of a 12yearold boy is reported. Chondromyxoid fibroma of frontal bone is a rare lesion. Most cases are characterised by grm1 gene fusion or promoter swapping. Introduction chondromyxoid fibromas are rare, benign tumours that consist of immature myxoid mesenchymal tissue with features of primitive cartilaginous differentiation. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor accounting for less than 1% of all bone tumors. Complete local excision with tumorfree margins avoids the recurrence of cmf, the underlying tumor in this case report. Radiographic and histologic patterns of calcification in. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture.
Citations may include links to fulltext content from pubmed central and publisher web sites. It is characterized by the presence of spindleshaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and. Baker ac, rezeanu l, o laughlin s, unni k, klein mj, et al. Chondromyxoid fibroma of the frontal bone tatsuo morimura, 12 atsuhisa nakano, 1 tsuyoshi matsumoto, 1 and eiichi tani1 summary. Under a microscope, chondromyxoid fibromas have elements of benign cartilage chondroid, myxoid, and fibrous tissue. Sep 12, 2014 chondromyxoid fibroma cmf is a rare, benign bone tumour. Enneking msts staging system the enneking surgical staging system also known as the msts system for benign musculoskeletal tumors is based on radiographic characteristics of the tumor host margin. The lesion is never purely epiphyseal, but may extend into the subchondral b. Chondromyxoid fibroma can be classified based on imaging findings. Chondromyxoid fibroma typically occurs in children and young adults between the ages of 10 and 30, and accounts for less than 1 percent of all bone tumors. Chondromyxoid fibroma, curettage, cementation, functional outcome, case series, management, protocol background chondromyxoid fibroma cmf is a rare, benign bone tumour. The diagnosis of fibroma of the tendon sheath can be suggested when mr imaging.
Chondromyxoid fibroma of the sacrum and left iliac bone musculoskeletal imaging radiologicpathologic conferences of the university of texas m. Ct also readily depicts the cortical integrity of the lesion. The treatment of the secondary abc is based on the appropriate treatment. Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone. Calcification was found microscopically in 15 cases 34. With contrast injection, the central portion of the lesion may show no enhancement due to the myxoid component. July 27, 2017 056 the tumor may be discovered incidentally during radiography 1.
1052 418 1414 968 1506 1456 1544 176 341 462 626 69 745 805 392 1165 1064 1004 116 1470 1463 680 126 236 1407 259 715 973 560